Notch Signaling in the Tumor Microenvironment
نویسندگان
چکیده
منابع مشابه
Tissue factor and PAR2 signaling in the tumor microenvironment.
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Dll4是定位于人染色体15q14、基因编码长度为685 个氨基酸的单链跨膜蛋白。它在进化过程中高度保守, 人和鼠Dll4基因编码的蛋白具有87%的同源序列。Dll4 的胞外段含有与Notch受体结合必需的8个表皮生长因子 (epidermal growth factor, EGF)样重复序列、4个潜在的 糖基化位点和1个由45个氨基酸组成的保守DSL(Delta, Serrate, Lag2)结构域。 Dll4通过与相邻细胞膜上的Notch1或Notch4受体相 互结合,使Notch受体经过一系列蛋白酶裂解。这个过 程主要包含2个蛋白酶,即肿瘤坏死因子α转换酶(tumor necrosis factor α-converzyme, TACE)和早老素(presenilin) 或称为γ-分泌酶(γ-secretase),受体裂解后释放出活化 形式的胞内区域(notch intrace...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2018
ISSN: 1535-6108
DOI: 10.1016/j.ccell.2018.07.009